Mesothelioma Chemotherapy with Cisplatin
Cisplatin, also known by its brand name Platinol, works by creating a platinum complex that binds to DNA and cross-links it. A DNA cross-link is the result of a reaction between either a natural agent or a chemical agent with two different positions along the DNA. Keep in mind that DNA is a double helix, meaning it has two strands that form a spiral shape. Since there are two strands, cross-linking can take place either intrastrand (on the same strand) or interstrand (on the opposite strand).
In the case of cisplatin, its primary cross-link is at the N7 position of neighboring guanine nucleotides, causing intrastrand cross-links that damage the cell’s DNA. This activates the repair mechanisms for DNA, which finds that the cells are not salvageable. The mechanism than triggers the death of those cells instead.
In addition, the damage also stops the growth of new cells because the crosslink inhibits the production of purine, which is necessary for the formation of both RNA and DNA. Without RNA and DNA, the cancer cells cannot reproduce themselves through cell division.
How is Mesothelioma Chemotherapy Drug Cisplatin Administered?
The combination of Alimta (pemetrexed) and Platinol is the most effective mesothelioma chemotherapy drug combination for the treatment of mesothelioma and has become the standard of care.
The drugs are administered in the following method:
Day 1 of the 21-day mesothelioma chemotherapy cycle, 500mg/m2 of Alimta administered intravenously. Thirty minutes later, 75 mg/m2 of cisplatin administered intravenously.
The dosage amount of mg/m2 means milligrams per square meter of body surface area (BSA). There are different formulas to measure BSA, but the one that is most often used is Mosteller’s, published in The New England Journal of Medicine in 1987. However, in actual practice, an adult’s BSA is considered to be 1.7 m2.
What Side Effects can Result From Taking Mesothelioma Chemotherapy Drug Cisplatin?
Medline Plus, a service of the U.S. National Library of Medicine, lists the following side effects and recommendations regarding whether or not your doctor should be called:
Cisplatin side effects are common and may include:
- Thinned or brittle hair
- Loss of appetite or weight
- Nausea and vomiting
- Changes in taste
- Numbness or tingling in the fingertips and toes
Tell your doctor if the following symptoms are severe or last for several hours:
If you experience any of the following symptoms, contact your doctor immediately:
- Unusual bruising or bleeding
- Black, tarry stools
- Dizziness or feeling of faintness
- Pain in your side or back
- Shortness of breath or wheezing
- Swelling of the feet or ankles
Special Instructions for Use of Cisplatin for Mesothelioma Chemotherapy
Cisplatin causes cumulative kidney damage. That’s why kidney function and magnesium, sodium, potassium and calcium levels should be checked before starting cisplatin treatment and before each course of therapy. To maintain the correct level of urine output and to reduce toxicity, patients should receive intravenous hydration with 1-2 liters of fluid over 8-12 hours before treatment, followed by adequate hydration for the next 24 hours.
Your firm has made this stressful process easy and comfortable for me.- Stephen
I couldn’t have done it without you.- Sam
The professionals at Shrader & Associates did the work, hassle free, and ensured I was able to leave a legacy for my family.- Raymond
Your team stood by me throughout the entire process.- Frank
Thanks to you, the grief of my loss would have been almost unbearable otherwise.- Brian
Our skilled approach to the practice of law has resulted in top ratings & awards from renowned legal organizations.
Our attorneys have been invited into some of the most prestigious and recognized professional associations in the U.S.
We’ve been featured on local and national news programs for our legal knowledge and winning results.
To date, we’ve secured countless million-dollar results for clients located throughout the country.
Mesothelioma cases require technical knowledge and an understanding of complex laws. An attorney with experience trying these claims and substantial resources to leverage on your behalf is your best bet to having a strong case. We are nationally recognized for providing quality representation to mesothelioma patients and their families.